Asle pharmaceuticals

Next-V

Indications and effects: Erectile dysfunction (patients who are unable to achieve and maintain an erection sufficient for satisfactory sexual activity)

Contraindication

Patients with a history of hypersensitivity to the components of this product.
Patients receiving nitrates or nitric oxide donors (nitroglycerin, amyl nitrite, isosorbide nitrate, nicorandil, etc.)
Patients for whom sexual activity is considered inappropriate, such as those with cardiovascular disorders.
Patients with severe hepatic dysfunction.
Patients with hypotension (blood pressure < 90/50 mmHg) or uncontrolled hypertension with treatment (resting systolic blood pressure >170mmHg or resting diastolic blood pressure >100mmHg)
Patients with a history of cerebral infarction, cerebral hemorrhage, or myocardial infarction within the last 6 months.
Patients with retinitis pigmentosa [A small number of patients with retinitis pigmentosa have a genetic disorder of phosphodiesterase.
Patients receiving amiodarone hydrochloride (oral).
Patients receiving soluble guanylate cyclase (sGC) stimulator (Riociguat)

Dosage and Administration

The usual oral dosage for adults is 25 mg to 50 mg of sildenafil once daily, approximately one hour before sexual activity.
Since it has been observed that the plasma concentration of this drug increases in elderly patients (65 years and older), patients with hepatic impairment, and patients with severe renal impairment (Ccr < 30 mL/min), 25 mg should be used as the starting dose.
The daily dose should be one time, and the interval between doses should be at least 24 hours.
Administration of this drug with a meal may delay the onset of effect compared to administration on an empty stomach.

Cautions for use

Sexual activity poses a risk to the heart, so pay attention to cardiovascular status before starting treatment for erectile dysfunction.
Prolonged or sustained erection lasting more than 4 hours (painful erection lasting more than 6 hours) has been reported in a small number of foreign post-marketing adverse events. If symptoms of an erection lasting more than 4 hours are observed, patients should be instructed to seek medical advice immediately because failure to promptly treat persistent erections may result in damage to penile tissue or permanent impairment of erectile function.
Since dizziness and visual disturbances have been observed in clinical trials, caution should be exercised when driving a car or operating machinery.
Patients should be instructed to discontinue taking the drug and seek immediate medical attention from an ophthalmologist if they experience a sudden decrease in vision or a sudden loss of vision after taking the drug.